Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications
نویسندگان
چکیده
منابع مشابه
Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications.
Epidermal growth factor receptor (EGFR) has fundamental roles in normal physiology and cancer, making it a rational target for cancer therapy. Surprisingly, however, inhibitors that target canonical, ligand-stimulated EGFR signaling have proven to be largely ineffective in treating many EGFR-dependent cancers. Recent evidence indicates that both intrinsic and therapy-induced cellular stress tri...
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ژورنال
عنوان ژورنال: Trends in Cell Biology
سال: 2016
ISSN: 0962-8924
DOI: 10.1016/j.tcb.2015.12.006